Faculty and Staff Detail
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Anna Kozak, M.S. Assistant Research Scientist Clinical Administrative Pharmacy |
| Contact Information | |
|---|---|
| Phone: | 706-733-0188, ext. 2 |
| Email: | akozak@mail.mcg.edu |
| Fax: | 706-721-3994 |
| Office: | |
| Address: |
Medical College of Georgia UGA Clinical Pharmacy Program, HM-1200 Augusta, GA 30912 |
| Biosketch | |||
|---|---|---|---|
| Research Coordinator | University of Georgia | 2003-2005 | |
| Research Project Coordinator | Medical College of Georgia | 2002-2003 | |
| Research Assistant III | Medical College of Georgia | 1999-2002 | |
| Senior Technical Associate | Lovelace Respiratory Research Institute | 1996-1999 | |
- Area of Expertise
- Blood pressure and temperature telemetry in rodents.
Stroke model in rats.
- Representative Publications
- 1. Kozak, W., I. Archuleta, K.P. Mayfield, A. Kozak, K. Rudolph, and M.J. Kluger. Inhibitors of alternative pathways of arachidonate metabolism differentially affect fever in mice. Am. J. Physiol. 275:R1031-R1040, 1998.
2. Mayfield KP, Kozak A, Rudolph K, Kluger MJ. Morphine suppresses development of fever to lipopolysaccharide in rats. Ann NY Acad Sci 856:281-285.
3. Mayfield KP, Soszynski D, Kozak W, Kozak A, Rudolph K and Kluger MJ. -Adrenergic receptor subtype effects on stress fever and thermoregulation. NeuroImmunoModulation 6:305-317, 1999.
4. Kozak W, Mayfield KP, Kozak A and Kluger MJ. Proadifen (SKF-525A), an inhibitor of cytochrome P-450, augments LPS-induced fever and exacerbates prostaglandin E2 levels in the rat. J therm Biol 25:45-50, 2000.
5. Kozak W, Kluger MJ, Kozak A, Wachulec M and Dokladny K. Role of cytochrome P-450 in endogenous antipyresis. Am J Physiol 279:R455-R460, 2000.
6. Singh SP, Kalra R, Puttfarcken P, Kozak A, Tesfaigzi J, Sopori ML. Acute and chronic nicotine exposures modulate the immune system thorugh different pathways. Toxicol Appl Pharmacol 164:65-72, 2000.
7. Kozak W, Kluger MJ, Tesfaigzi J, Kozak A, Mayfield KP, Wachulec M and Dokladny K. Molecular mechanisms of fever and endogenous antipyresis. Ann NY Acad Sci 917:121-134, 2000.
8. Dokladny, K., A. Kozak, M. Wachulec, E.S. Wallen, M.G. Menache, W. Kozak, M.J. Kluger, and P.L. Moseley. Effect of heat stress on LPS-induced febrile response in D-galactosamine-sensitized rats. Am. J. Physiol. 280:R338-R344, 2001.
9. Henderson RF, Barr EB, Blackwell WB, Clark CR, Conn CA, Karla R, March TH, Sopori ML, Tesfaigzi y, Menache MG, Mash DC, Dokladny K, Kozak W, Kozak A, Wachulec M, Rudolph K, Kluger MJ, Singh SP, Razani-Boroujerdi S, Langley RJ. Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential cause of Gulf War illness. Toxicol Ind Health. 2001 Jun; 17(5-10):294-7.
10. Conn CA, Dokladny K, Menache MG, Barr EB, Kozak W, Kozak A, Wachulec M, Rudolph K, Kluger MJ, Henderson RF. Effects of sarin on temperature and activity of rats as a model for gulf war syndrome neuroregulatory functions. Toxicol. Appl. Pharmacol. 184(2): 77-81,2002
11. Kozak W, Kozak A. Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using NOSgene deficient mice. J Appl Physiol. 2003 Jun; 94 (6): 2534-44
12. Kozak W., D. M. Aronoff, O. Boutaud, and A. Kozak. 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. J. Exp. Biol. Med. 2003 Jul; 228(7): 786-94.
13. Harris AK, Ergul A, Kozak A, Machado LS, Johnson MH, Fagan SC. Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke. BMC Neurosci. 2005 Aug 3; 6:49.
14. Kozak W, Wrotek S, Kozak A. Pyrogenicity of CpG-DNA in mice: Role of interleukin-6, cyclooxygenases, and nuclear-factor-kappa-B. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005 Nov 17.
15. Fagan, SC., Kozak, A., Hill, W.D., Pollock, D.M., Xu, L., Johnson, M.H., Ergul, A., Hess, D.C. Hypertesion after experimental cerebral ischemia: candesartan provides neurovascular protection. J. Hypertension. 2006 Mar;24(3):535-9.
16. Machado LS, Kozak A, Ergul A, Hess DC, Borlongan CV, Fagan SC. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci. 2006 Jul 17;7:56.
17. Elewa HF, Kozak A, Johnson MH, Ergul A, Fagan SC. Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection. J Hypertens. 2007 Apr;25(4):855-9.
18. Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, Hall C, Kozak A, Fagan SC. Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol. 2007 Oct 15;7:33.
19. Kozak W, Kozak A, Johnson MH, Elewa HF, Fagan SC. Vascular protection with candesartan after experimental acute stroke in hypertensive rats: a dose-response study. J Pharmacol Exp Ther.2008 Sep;326(3):773-82.
20. Kozak A, Ergul A, El-Remessy, AB, Johnson MH, Elewa HF, Abdelsaid M, Wiley DC, Fagan SC. Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. Stroke, in press.
- Other
- Abstracts
1. Kozak, W., I. Archuleta, K.P. Mayfield, A. Kozak, and M.J. Kluger. Inhibitors of cytochrome P-450 potentiate fever in rats and mice: a possible pathway for the regulation of fever' ceiling. FASEB J., 1998, 12(5), A730/4237.
2. Kozak, W., K.P. Mayfield, A. Kozak, M.J. Kluger. Proadifen (SKF-525A), an inhibitor of cytochrome P-450, augments LPS-ind uced fever and exacerbates prostaglandin-E2 levels in the rat. XI International Symposium “Pharmacology of Thermoregulation” Sevilla (Spain), May 9-13, 1999.
3. Kozak, W., M.J. Kluger, J. Tesfaigzi, M. Wachulec, A. Kozak, and K. Dokladny. Molecular mechanism of fever and antipyresis. The 4th International Congress of the International Society for Neuroimmunomodulation. Sept 30th, 1999. Lugano, Switzerland. Abstracts: Neuroimmunomodulation, 6(6):394(A5), 1999.
4. Kozak, W., M.J. Kluger, A. Kozak, and M. Wachulec. Brain epoxygenase may be involved in regulation of lipopolysaccharide (LPS)-induced fever in rats. 30th Annual Meeting, Society for Neuroscience, November 4-9, 2000. Abstracts, 26(2): 649,15, p. 1741.
5. Kozak, W., A. Kozak, J. Tesfaigzi. Sickness behavior during lung inflammation: effect of cytochrome P-450 modulators. FASEB J. 15(5):A925, 2001 (abstract # 717.6). Annual Meeting of Experimental Biology 2001. Orlando, Florida, March 31-April 4, 2001.
6. Conn, C.A., K. Dokladny, M.G. Menache, E.B. Barr, W. Kozak, A. Kozak. M. Wachulec, K. Rudolph, M.J. Kluger, R.F. Henderson. Effect of acute inhalation exposure to low levels of sarin on temperature and activity of rats. FASEB J. 15(5):A1109, 2001 (abstract # 876.16). Annual Meeting of Experimental Biology 2001. Orlando, Florida, March 31-April 4, 2001.
7. Kozak, W., M.J. Kluger, and A. Kozak. Role of cytochrome P-450 in fever. Experimental Biology, New Orleans, April 20-24, 2002. FASEB J. 16(5):650.6, 2002.
8. Kozak, A., A. Ergul, A. Kutlar, M.J. Kluger, and W. Kozak. Role of cytochrome P-450 in sickle cell-induced sickness behavior. Experimental Biology, New Orleans, April 20-24, 2002. FASEB J. 16(5):459.11, 2002.
9. Kozak, W., A. Kozak, A.Ergul, A. Kutlar and M.J.Kluger. Sickled erythrocyte-induced sickness behavior in rats can be attenuated by dieting a cytochrome P-450/ epoxygenase inducer. 4th International Congress of Pathophysiology, Budapest, Hungary, June 29-July 5, 2002.
10. Daniels, E.R., A. Kozak, M. W.Brands, J. D. Imig, E. W. Inscho, W. Kozak, D. M. Pollock, and R. C. Webb. Interleukin-6 Is Required for the Chronic Phase of Angiotensin II Induced Hypertension in Mice. 56 Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. Orlando, Florida, September 25-28, 2002.
11. M achado, L.S., A. Kozak, A. Ergul, C.V. Borlongan, D.C. Hess, and S.C. Fagan. Minocycline inhibits MMPs 2 and 9 and may represent a potential therapeutic strategy after acute ischemic stroke. Georgia Life Sciences Summit, October 27, Atlanta, GA, 2005.
12. Fagan, S.C., A. Kozak, W.D. Hill, D.M. Pollock, L. Xu, M.H. Johnson,A. Ergul, and D.C. Hess. Hypertension after experimental stroke: Candesartan provides neurovascular protection. 59th AHA High Blood Pressure Council Meeting, September 21-24, Washington D.C. (Hypertension 46:a99, p848), 2005.
13. Ergul, A., A. Kozak, K. Sachidanandam, A.K. Harris, and S.C. Fagan. Increased intracerebral hemorrhage and altered infarct size and localization after experimental stroke in Type 2 diabetes. 66th Annual Meeting of American Diabetes Association, June 9-13, Washington D.C., 2006.
14. Elewa, HF, Elgebaly, M, Kozak, A, Pollock, D, Machado, L, Ergul, A, Hill, W and Fagan SC. (2006) Acute blood pressure lowering is neuroprotective in experimental cerebral ischemia. Graduate research day at MCG, March 17, Augusta, GA.
15. Elewa HF, Kozak A, Johnson MH, Ergul A, Fagan SC; Controlled blood pressure lowering after experimental cerebral ischemia provides neurovascular protection; Conference abstracts. Hypertension 2006;48;25-103
16. Elewa HF, Kozak A, Ergul A, Fagan SC. (2007) Vascular protection with atorvastatin after acute ischemic stroke in diabetes. Graduate research day at MCG, March 23, Augusta, GA.
17. Elewa HF, Kozak A, Johnson MH, Ergul A, Fagan SC; Controlled blood pressure lowering after experimental cerebral ischemia provides neurovascular protection; ACCP meeting April 21-25, 2007, Memphis, TN
18. Elewa HF, Kozak A, Rychly D, Ergul A, Frye R, El-Remessy A, Fagan SC; Atorvastatin reduces intracerebral hemorrhage after experimental stroke; AHA scientific sessions November 3-7, 2007, Orlando, FL
19. Kozak A, Ergul A, El-Remessy, Johnson M, Elewa HF, Willey D, Fagan SC. Candesartan augments ischemia-induced proangiogenic state and results in long-term improvement after stroke. Accepted for Stroke meeting February, 2009, San Diego, CA