Faculty and Staff Detail
|
Bradley Phillips, Pharm.D., BCPS, FCCP Millikan-Reeve Professor and Head CET Clinical Administrative Pharmacy |
| Contact Information | |
|---|---|
| Phone: | (706) 542-5317 |
| Email: | bgp@uga.edu |
| Fax: | (706)542-5228 |
| Office: | 249 |
| Address: |
R.C. Wilson Pharmacy Bldg 250 Green Street UGA College of Pharmacy Athens, GA 30602-2354 |
| Biosketch | |||
|---|---|---|---|
| Professor | Univ. of Georgia | 2007--present | |
| Associate Professor | Univ. of Iowa | 2001--2007 | |
| Director | Iowa GCRC Laboratory Core | 2001-2007 | |
| Assistant Professor | Univ. of Iowa | 1995--2001 | |
| Clinical Pharmacist | VAMC--Iowa CIty | 1995-2007 | |
| Fellowship--Cardiology | Univ. of Illinois--Chicago | 1993-1995 | |
| Doctor of Pharmacy | Medical College of South Carolina | 1991-1993 | |
| Clinical Pharmacist | Lion's Gate Hospital | 1990-1991 | |
| Pharmacy Resident | Lion's Gate Hospital | 1989-1990 | |
| Bachelor of Science in Pharmacy | Univ. of British Columbia | 1995-1989 | |
- Honors and Awards
- American College of Clinical Pharmacy/Merck Cardiovascular Fellowship Award, 1994
American Federation for Clinical Research Trainee Investigator Award, 1995
Marion Merrell Dow Fellowship Award for Excellence in Clinical Research, 1995
Study Sections: AHA CV (Patho)Physiology, 2002-2005
American College of Cardiology Young Investigator Award Finalist, 1998
American College of Clinical Pharmacy - Rhone-Poulenc Rorer Cardiovascular Research Award, 1998.
Sleep Academic Award form the National Institutes of Health, 1999
American College of Clinical Pharmacy Young Investigator Award, 2001
American College of Clinical Pharmacy/Merck Cardiovascular Fellowship Award, 2001
Fellow of the American College of Clinical Pharmacy, 2006.
- Area of Expertise
- My research is focused on understanding the mechanisms for cardiovascular disease in patients with sleep apnea. Understanding the mechanisms for cardiovascular disease in this population is important to appropriately manage and treat sleep apnea and co-existing cardiovascular disease in the clinical setting. For example, people with untreated sleep apnea are at a three fold higher risk for hypertension. Further, when hypertension is present it is often resistant to drug therapy until sleep disordered breathing is eliminated. Effectively treating sleep apnea can decrease blood pressure significantly.
Obstructive sleep apnea affects 15 million Americans and occurs in up to 5% of men and 3% of women. The common characteristics of obstructive sleep apnea include obesity, male gender, large neck circumference, daytime tiredness, fatigue, and snoring. One of the hallmark signs of sleep apnea is witnessed cessation of breathing during sleep. Although obstructive sleep apnea occurs in children and adolescents, it is more common in middle-aged adults with prevalence increasing with age. A diagnostic sleep study (polysomnography) determines the severity or number of episodes of apnea and hypopnea during sleep. The main treatment to alleviate obstructive sleep apnea is continuous positive airway pressure therapy. This type of therapy is delivered by a bedside machine that provides room air through a small mask secured over the nose during the night.
There are well established pathophysiologic factors, such as obesity, that explain the development and progression of cardiovascular disease. Other known factors include activation of the central sympathetic nervous system, increases in circulating catecholamine levels, impaired cardiovascular variability, and activation of the endothelin system. These well known mechanisms for cardiovascular disease also occur in relatively healthy people that just have obstructive sleep apnea. Patients with severe sleep apnea who are free of cardiovascular disease have impaired endothelium dependent vasodilation. This type of vasculopathy is seen early in hypertension, diabetes, heart failure and in arteriosclerosis. The presence of obesity worsens sleep apnea. The corollary to this may also be true as patients with sleep apnea have increased leptin resistance and weight gain. It appears that many of the known factors for poor cardiovascular heath also occur in sleep apnea. Emerging evidence suggests that untreated sleep apnea may predispose to cardiovascular disease.
Areas of expertise in clinical and translational research include microneurography (MSNA, SSNA), endothelial function (conduit and resistance vessels), hyperinsulinemic euglycemic and hypoglycemic clamps, assessment of vasoactive peptides, ambulatory blood pressure monitoring, anthropometric measurements.
- Representative Publications
- 1. Phillips BG, Schoen MD, Hoon TJ, Schrader BJ, Bauman JL, Rich S. Serum nifedipine concentrations and response of patients with pulmonary hypertension. Am J Cardiol. 1996;77:996-99.
2. Phillips BG, Yim JM, Brown EJ, Bittar N, Hoon TJ, Celestin C, Vlasses PH, Bauman JL. Pharmacologic management of acute myocardial infarction at academic hospitals in the United States. Am Heart J. 1996;131:872-8.
3. Evans RR, Phillips BG, Singh G, Bauman JL, Gulati A. Racial and gender differences in endothelin-1. Am J Cardiol. 1996:78:486-488.
4. Albers GW, Yim JM, Belew KM, Bittar N, Hattemer CR, Phillips BG, Kemp S, Hall EA, Morton DJ, Vlasses PH. Status of antithrombotic therapy for patients with atrial fibrillation in university hospitals. Arch Intern Med. 1996;156:2311-2316.
5. Phillips BG, Gandhi A, Sanoski C, Just V, Bauman JL. Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter. Pharmacotherapy. 1997;17:1238-1245.
6. Narkiewicz K, van de Borne PJH, Montano N, Dyken ME, Phillips BG, Somers VK. The contribution of tonic chemoreflex activation to increased sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation. 1998;97:943-945.
7. Narkiewicz K, Pesek C, Kato M, Phillips BG, Davison DE, Somers VK. Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea. Hypertension. 1998;32:1039-1043.
8. Phillips BG, Narkiewicz K, Pesek C, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens. 1999;17:61-66.
9. Phillips BG, Hisel TM, Pesek CA, Kato M, Dyken ME, Narkiewicz K, Somers VK. Recent weight gain in patients with newly diagnosed obstructive sleep apnea. J Hypertens. 1999;17:1297-1300.
10. Kato M, Roberts-Thomson P, Phillips BG, Narkiewicz K, Haynes WG, Pesek CA, Somers VK. The effects of short term passive smoke exposure on endothelium-dependent and independent vasodilation. J Hypertens. 1999;17:1395-1401.
11. Narkiewicz K, Kato M, Phillips BG, Pesek C, Davison DE, Somers VK. Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. Circulation. 1999;100:2332-2335.
12. Phillips BG, Somers VK. Neural and humoral mechanisms mediating cardiovascular responses to obstructive sleep apnea. Resp Physiol 2000; 119:181-187.
13. Narkiewicz K, Phillips BG, Somers VK. Influence of Sleep and Sleep Apnea on Autonomic Control of the Cardiovascular System. In: Bradley TG, Flores JS, eds. Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Marcel Dekker NIH Series, New York, NY, 2000, pp. 135-158.
14. Phillips BG, Somers VK. Drug Information Handbook for Cardiology. (1st ed). Lexi-Comp Inc., Hudson, OH. 2000, 2001.
15. Kato M, Phillips BG, Sigurdsson G, Narkiewicz K, Pesek CA, Somers VK. Effects of sleep deprivation on neural circulatory control. Hypertension. 2000;35:1173-1175.
16. Phillips BG, Kato M, Narkiewicz K, Choe I, Somers VK. Increases in leptin levels, sympathetic drive and weight gain in obstructive sleep apnea. Am J Physiol – Heart. 2000;279:234-237.
17. Schroeder KE, Narkiewicz K, Kato M, Pesek C, Phillips BG, Davison D, Somers VK. Personality type and neural circulatory control. Hypertension. 2000;36:830-833.
18. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, Somers VK. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation. 2000;102:2607-2610.
19. Phillips BG, Kato M, Pesek C, Winnicki M, Narkiewicz K, Davison D, Somers VK. Sympathetic activation by sildenafil. Circulation. 2000;102:3068-3073.
20. Sivitz WI, Herlein JA, Morgan DA, Fink BD, Phillips BG, Haynes WG. Effect of acute and antecedent hypoglycemia on sympathetic activity and catecholamine responsiveness in normal rats. Diabetes 2001:50:1119-1125.
21. Narkiewicz K, Kato M, Phillips BG, Pesek C, Choe I, Palantini P, Sivitz WI, Somers VK. Leptin interacts with heart rate but not sympathetic nerve traffic in healthy humans. J Hypertens 2001: 19:1089-94.
22. Winnicki M, Phillips BG, Accurso V, Van de Borne P, Shamsuzzaman A, Patil K, Narkiewicz K, Somers VK. An independent association between plasma leptin levels and heart rate in heart transplant recipients. Circulation 2001;104:384-386.
23. Phillips BG, Somers VK. Sleep disordered breathing and risk for cardiovascular disease. Curr Opin Pulm Med 2002; 8:516-20.
24. Narkiewicz K, Winnicki M, Schroeder K, Phillips BG, Kato M, Cwalina E, Somers VK. Relationship between muscle sympathetic nerve activity and diurnal blood pressure profile. Hypertension 2002:39:168-172.
25. Hoffman RP, Sinkey CA, Dopp JM, Phillips BG. Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects. Diabetes 2002;51:734-742.
26. Winnicki M, Somers VK, Accurso V, Phillips BG, Puato M, Palatini P, Pauletto P. Fish-rich diet, leptin and body mass. Circulation 2002;106:289-291.
27. Hoffman RP, Sinkey CA, Dopp JM, Phillips BG. Lack of effect of alpha- and beta-adrenergic inhibition on forearm glucose uptake despite differences in forearm blood flow in healthy humans. Metabolism 2002;51:1506-1513.
28. Phillips BG, Somers VK. Cardiovascular Disease Mechanisms in Sleep Apnea. In: Braunwald E. ed. Harrison’s Principles of Internal Medicine Online. McGraw Hill, New York, NY. 2003.
29. Herlein JA, Fink BD, Morgan DA, Phillips BG, Haynes WG, Sivitz WI. Leptin administration to normal rats does not alter catecholamine responsiveness to insulin-induced hypoglycemia. Metabolism 2003;52:1484-90.
30. Phillips BG, Somers VK. Hypertension and obstructive sleep apnea. Curr Hypertens Rep 2003; 5:380-385.
31. Shamsuzzaman ASM, Winnicki M, Wolk R, Svatikova A, Phillips BG, Berger P, Somers VK. An independent Association between plasma leptin and C-reactive protein in healthy humans. Circulation 2004 2004;109:2181-5.
32. Svatikova A, Wolk R, Magera MJ, Shamsuzzaman AS, Phillips BG, Somers VK. Plasma Homocysteine in Obstructive Sleep Apnea. Eur Heart J 2004;25:1325-9.
33. Svatikova A, Shamsuzzaman ASM, Wolk R, Phillips BG, Olson LJ, Somers VK. Plasma brain natriureturetic peptide in obstructive sleep apnea. Am J Cardiol 2004; 15:1325-9.
34. Deshmukh S, Phillips BG, O’Dorisio T, Flanigan MJ, Lim VS. Hormonal responses to fasting and re-feeding in chronic renal failure patients. Am J Physiol Endocrinol Metab 2005; 288(1):E47-55.
35. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. A Gender selective interaction between aging and sympathetic nerve activity. Hypertension 2005; 45(4): 522-5.
36. Herlein JA, Morgan DA, Phillips BG, Haynes WG, Sivitz WI. Effect of antecedent hypoglycemia on sympathetic neural and adrenal responses to subsequent hypotension. Endocrinology 2006; 147:2781-8.
37. Dopp JM, Phillips BG. Sleep Disorders, in DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM (eds): Pharmacotherapy: A Pathophysiologic Approach, 7th Edition. McGraw-Hill, New York, NY. 2008 pp 1191-1202.
38. Dopp JM, Phillips BG. Sleep Disorders, in Chisholm MA, Schwinghammer TL, Wells BG, DiPiro JT, Kolesar JM, Malone PM (eds): Pharmacotherapy Principles & Practice, 1st Edition. McGraw-Hill, New York, NY. 2007 pp 621-632.
39. Phillips BG. Cardiovascular Disorders: Atrial Fibrillation, in Schwinghamer TL & Koehler JM, eds: Pharmacotherapy Case Book: A Patient-Focused Approach. McGraw-Hill, New York, NY, 2009 pp56-58.
40. Dopp JM, Phillips BG, Sleep Disorders. In: Dunsworth T, Richardson M, Chant C, Cheng JWM, Shessman KH, Hume AL, et al, eds. Pharmacotherapy Self-Assessment Program, 6th ed. Pulmonary/Critical Care. Lenexa, KS: American College of Clinical Pharmacy, 2008: 43-57.
41. Svatikova A, Olson LJ, Wolk R, Phillips BG, Adachi T, Schwartz GL, Somers VK. Obstructive Sleep Apnea and Aldosterone. Sleep 2009; (in press).
42. Narkiewicz K, Sert FH, Somers VK, Phillips BG. Influence of Sleep and Sleep Apnea on Autonomic Control of the Cardiovascular System. In: Bradley TG, Flores JS, eds. Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Marcel Dekker NIH Series, New York, NY, 2009; in press.